Center Path Institute's South Building is intended for any individual who requires additional support from campus staff regarding mental health, or any other chronic disorders or disabilities; of course, this is presuming that the profundity of whatever may affect the individual does not warrant residency in the West Building. Conditions that may render an individual elligble for residency within the South Building may range from a person who does not have full use of their body (e.g., partial or complete paralysis of limb(s); deaf, blind, or mute individuals) to those who, as consequence of a given mental health condition, require additional monitoring (e.g., certain eating disorders; certain thought disorders) but do not pose a risk requiring 'intervention'--that is, immediate and urgent support. Additionally, on-campus residents are encouraged to enroll in a residency program in the South Building, which is intended to help alleviate certain stigmas or erase social barriers that may be associated with the individuals who must live in the South Building.

The South Building is reminiscent of the East Building (where most students end up residing) but it is slightly older by under a decade, and has not been renovated at all. Thus, a significant portion of the building--if not the entirety of the building--carries the aesthetic that one might expect of a particularly poorly-funded school house, or of an antiquated library. Most furnishings are made of wood, and the walls are typically painted in one or more shades of an unoffensive natural tone like nougat or olive. Furniture which is more easily replaced, or perhaps more appropriately more often demands replacement, such as refrigeration devices or cookware, are however new.

Dorm rooms in the South Building are generally not subjected to any kind of blanket restriction on objects permitted inside, save for all forms of bladed or puncturing instruments; it is arguable that, depending on the individual, a bladed instrument may pose an unnecessary threat to their safety (e.g., if the person is blind) or may elicit a relapse in self-injurious behaviors by their presence alone. However, most occupants may simply have something like a certain deficiency, require medication, or have something like narcolepsy.